Reference Type:  Dataset
Investigators: Sólja Remisdóttir Veyhe (1,2), Oriane Cédile (1,2,3,4), Sara Dahlmann (1,2), Jakub Krejcik (1,2,3), Niels Abildgaard (1,2,3), Thor Høye (5), Michael Boe Møller (1,6), Mads Thomassen (7,8), Karen Juul-Jensen (1,3), Henrik Frederiksen (1,3), Karen Dybkær (5), Marcus Høy Hansen* (1,2,3), Charlotte Guldborg Nyvold* (1,2,3,4)

1) Haematology-Pathology Research Laboratory, Research Unit for Haematology and Research Unit for Pathology, University of Southern Denmark (SDU) and Odense University Hospital (OUH), Odense, Denmark 
2) CITCO, Centre for Cellular Immunotherapy of Haematological Cancer Odense, OUH, Odense, Denmark (DK)
3) Department of Haematology, OUH, Odense, DK 
4) OPEN, Odense Patient data Explorative Network, OUH, Odense, DK
5) Department of Clinical Medicine, Aalborg University Hospital, Aalborg, DK
6) Department of Pathology, OUH, Odense, DK 
7) Department of Clinical Genetics, OUH, Odense, DK
8) Clinical Genome Center, Department of Clinical Research, SDU, Odense, DK


Year: 2024
Title: Molecular composition, clonality and kinetics of B cell compartment in patients with chronic lymphocytic leukemia during ibrutinib treatment
Distributor: Harvard Dataverse
Original Release Date: Mon Jun 03 03:37:45 EDT 2024
Version: DRAFT VERSION
Short Title: Molecular composition, clonality and kinetics of B cell compartment in patients with chronic lymphocytic leukemia during ibrutinib treatment
DOI: doi:10.7910/DVN/RFNWTV
Keywords: Chronic lymphocytic leukemia
URL: https://doi.org/10.7910/DVN/RFNWTV


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Introduction
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The deposited data contains data from next-generation sequencing. Available files are variants (DNA and RNA) for the assessment of allelic imbalances, RNA expression tables, targeted coverage profiles, 10X single-cell data (h5), and somatic variants in Excel format.

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Filenames
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Coverage: *.dedup.recal.paired.bed
DNA/RNA and CD3+ control-paired somatic variants: I/V_*_Mutect2nRNA.xlsx
DNA variants for assessment of allelic imbalance (ALT stripped due to ethical ethical concerns): DNA_*.dedup.recal.SNP.filtered.dp100.vcf
RNA variants: RNA_*.filtered.dp30.vcf
RNA expression: *.symbolcounts.tsv